General Information

  • ID:  hor001094
  • Uniprot ID:  NA
  • Protein name:  SDPYLFRamide
  • Gene name:  NA
  • Organism:  Lymnaea stagnalis
  • Family:  FMRFamide related peptide family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  SDPYLFR
  • Length:  7
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T7 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Hyperpolarizes isolated egg-laying hormone cells;stimulate the heart
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001094_AF2.pdbhor001094_ESM.pdb

Physical Information

Mass: 100419 Formula: C42H60N10O12
Absent amino acids: ACEGHIKMNQTVW Common amino acids: DFLPRSY
pI: 6.34 Basic residues: 1
Polar residues: 2 Hydrophobic residues: 2
Hydrophobicity: -72.86 Boman Index: -1928
Half-Life / Aliphatic Index: 1.9 hour Aliphatic Index: 55.71
Instability Index: 857.14 Extinction Coefficient cystines: 1490
Absorbance 280nm: 248.33

Literature

  • PubMed ID:  2002360
  • Title:  The Lymnaea Cardioexcitatory Peptide (LyCEP) Receptor: A G-protein-coupled Receptor for a Novel Member of the RFamide Neuropeptide Family