General Information

  • ID:  hor001093
  • Uniprot ID:  O97371
  • Protein name:  RFamide
  • Gene name:  NA
  • Organism:  Lymnaea stagnalis (Great pond snail) (Helix stagnalis)
  • Family:  FMRFamide related peptide family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Lymnaea (genus), Lymnaeidae (family), Lymnaeoidea (superfamily), Hygrophila, Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  TPHWRPQGRF
  • Length:  10(24-33)
  • Propeptide:  MKTSQIMISTCCVLSVIFSLCYATPHWRPQGRFGKRTTEDDNVPDFGISRLQDIPIELMFSKNELSRRNSKPRLCSTSGVVDTRPAMHKSMRCK
  • Signal peptide:  MKTSQIMISTCCVLSVIFSLCYA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-O97371-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001093_AF2.pdbhor001093_ESM.pdb

Physical Information

Mass: 144214 Formula: C59H84N20O13
Absent amino acids: ACDEIKLMNSVY Common amino acids: PR
pI: 12.5 Basic residues: 3
Polar residues: 2 Hydrophobic residues: 2
Hydrophobicity: -181 Boman Index: -3636
Half-Life / Aliphatic Index: 7.2 hour Aliphatic Index: 0
Instability Index: 4464 Extinction Coefficient cystines: 5500
Absorbance 280nm: 611.11

Literature

  • PubMed ID:  9822740
  • Title:  The Lymnaea Cardioexcitatory Peptide (LyCEP) Receptor: A G-protein-coupled Receptor for a Novel Member of the RFamide Neuropeptide Family