General Information

  • ID:  hor001063
  • Uniprot ID:  A0A183CIN0
  • Protein name:  Neuropeptide AF8
  • Gene name:  gpflp-2
  • Organism:  Globodera pallida (Potato cyst nematode)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  neurones associated with the circumpharyngeal nerve ring and specifically in a number of cell bodies in the lumbar ganglia of the perianal nerve ring.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Globodera (genus), Heteroderinae (subfamily), Heteroderidae (family), Tylenchoidea (superfamily), Tylenchomorpha (infraorder), Tylenchina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  KSAYMRF
  • Length:  7
  • Propeptide:  MMWSLFFILFSCFIFRPASSDLLSSSTDAQLQQLCARFPGMEVCQPDDEALGAMAKRKSAYMRFGRAAAEQEPVMEKRKSAYMRFGKRSPEDENVDQLLALNEPDAQQMEKRKSAYMRFGKRKSAYMRFGRK
  • Signal peptide:  MMWSLFFILFSCFIFRPASS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Regulation of both dorsal and ventral body wall muscles, the musculature of the vulva and in the function of a number of sensory structures in both the head and tail
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A0A183CIN0-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001063_AF2.pdbhor001063_ESM.pdb

Physical Information

Mass: 100927 Formula: C41H63N11O10S
Absent amino acids: CDEGHILNPQTVW Common amino acids: AFKMRSY
pI: 10.45 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 2
Hydrophobicity: -57.14 Boman Index: -1687
Half-Life: 1.3 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 14.29
Instability Index: 6057.14 Extinction Coefficient cystines: 1490
Absorbance 280nm: 248.33

Literature

  • PubMed ID:  12117492
  • Title:  Localisation of Globodera Pallida FMRFamide-related Peptide Encoding Genes Using in Situ Hybridisation