General Information

  • ID:  hor001053
  • Uniprot ID:  NA
  • Protein name:  FMRFamide-related peptide
  • Gene name:  NA
  • Organism:  Drosophila melanogaster
  • Family:  FMRFamide related peptide family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  DEGHKMLYF
  • Length:  9
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T9 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Increased heart rate significantly
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001053_AF2.pdbhor001053_ESM.pdb

Physical Information

Mass: 128217 Formula: C52H74N12O15S
Absent amino acids: ACINPQRSTVW Common amino acids: DEFGHKLMY
pI: 5.45 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 2
Hydrophobicity: -81.11 Boman Index: -1469
Half-Life / Aliphatic Index: 1.1 hour Aliphatic Index: 43.33
Instability Index: 7142.22 Extinction Coefficient cystines: 1490
Absorbance 280nm: 186.25

Literature

  • PubMed ID:  10818250
  • Title:  Native and heterologous neuropeptides are cardioactive in Drosophila melanogaster