HORDB

General Information

ID: hor001047
Uniprot ID: NA
Protein name: KHKNYLRFamide
Gene name: NA
Organism: Cancer magister
Family: FMRFamide related peptide family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: NA
GO MF: NA
GO BP: NA
GO CC: NA

Sequence Information

Sequence: KHKNYLRF
Length: 8
Propeptide: NA
Signal peptide: NA
Modification: T8 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Activity

Function: Be a potent modulator of the C. borealis stomatogastric and cardiac neural circuits.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure

Disulfide bond: NA
Structure ID: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001047_AF2.pdb

hor001047_ESM.pdb

Physical Information

Mass:	123034	Formula:	C52H80N16O11
Absent amino acids:	ACDEGIMPQSTVW	Common amino acids:	K
pI:	10.9	Basic residues:	4
Polar residues:	2	Hydrophobic residues:	2
Hydrophobicity:	-171.25	Boman Index:	-2956
Half-Life / Aliphatic Index:	1.3 hour	Aliphatic Index:	48.75
Instability Index:	6242.5	Extinction Coefficient cystines:	1490
Absorbance 280nm:	212.86

Literature

PubMed ID: 16515542
Title: Mass spectrometric characterization and physiological actions of GAHKNYLRFamide, a novel FMRFamide-like peptide from crabs of the genus Cancer.