General Information

  • ID:  hor001047
  • Uniprot ID:  NA
  • Protein name:  KHKNYLRFamide
  • Gene name:  NA
  • Organism:  Cancer magister
  • Family:  FMRFamide related peptide family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  KHKNYLRF
  • Length:  8
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T8 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Be a potent modulator of the C. borealis stomatogastric and cardiac neural circuits.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001047_AF2.pdbhor001047_ESM.pdb

Physical Information

Mass: 123034 Formula: C52H80N16O11
Absent amino acids: ACDEGIMPQSTVW Common amino acids: K
pI: 10.9 Basic residues: 4
Polar residues: 2 Hydrophobic residues: 2
Hydrophobicity: -171.25 Boman Index: -2956
Half-Life: 1.3 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 48.75
Instability Index: 6242.5 Extinction Coefficient cystines: 1490
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  16515542
  • Title:  Mass spectrometric characterization and physiological actions of GAHKNYLRFamide, a novel FMRFamide-like peptide from crabs of the genus Cancer.