HORDB

ID: hor001031
Uniprot ID: Q6TUI8
Protein name: Neuropeptide AF17
Gene name: NA
Organism: Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Family: FMRFamide related peptide family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Ascaris (genus), Ascarididae (family), Ascaridoidea (superfamily), Ascaridomorpha (infraorder), Spirurina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: NA
GO CC: NA

Sequence: FDRDFMHF
Length: 8
Propeptide: DRNFMNFGKRESQFSRDFLNFGKRESSVRSLKQYYDDLRQKKDFDRDFMHFGKRSDAFSRNFMNFGKRDDAFSRDFLSFGKRR
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Produced paralysis and loss of waveforms, increased body length and decreased cAMP
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001031_AF2.pdb

hor001031_ESM.pdb

Mass:	123928	Formula:	C52H67N13O13S
Absent amino acids:	ACEGIKLNPQSTVWY	Common amino acids:	F
pI:	5.41	Basic residues:	2
Polar residues:	0	Hydrophobic residues:	3
Hydrophobicity:	-55	Boman Index:	-2573
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	2 min	Aliphatic Index	0
Instability Index:	6396.25	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 11087928
Title: Changes in locomotory behavior and cAMP produced in Ascaris suum by neuropeptides from Ascaris suum or Caenorhabditis elegans