HORDB

ID: hor000985
Uniprot ID: E2E4E4
Protein name: Cholecystoxin-8
Gene name: NA
Organism: Varanus varius (Lace monitor lizard) (Lacerta varia)
Family: Gastrin/cholecystokinin family
Source: animal
Expression: Expressed by the mandibular venom gland.
Disease: NA
Comments: NA
Taxonomy: Varanus (genus), Varanidae (family), Varanoidea (superfamily), Paleoanguimorpha, Anguimorpha (infraorder), Toxicofera, Episquamata, Unidentata, Bifurcata, Squamata (order), Lepidosauria (class), Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity; GO:0090729 toxin activity
GO BP: GO:0007165 signal transduction; GO:0007586 digestion; GO:0008217 regulation of blood pressure; GO:0035821 modulation of process of another organism
GO CC: GO:0005576 extracellular region

Sequence: DYLGWMDF
Length: 8(94-101)
Propeptide: MYGGICLCVLLAVLAISSSGQHISRSLNGNSLAAAIEQNFPEKHRPARTPDSNQRVESNIDEKANLGVLLARYLQKARRGTNGKPPDPKKESQDYLGWMDFGRRSAEEYEYSS
Signal peptide: MYGGICLCVLLAVLAISSSG
Modification: T2 Sulfotyrosine;T8 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000985_AF2.pdb

hor000985_ESM.pdb

Mass:	117121	Formula:	C50H63N9O14S
Absent amino acids:	ACEHIKNPQRSTV	Common amino acids:	D
pI:	3.49	Basic residues:	0
Polar residues:	2	Hydrophobic residues:	3
Hydrophobicity:	-13.75	Boman Index:	-406
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	48.75
Instability Index:	4435	Extinction Coefficient cystines:	6990
Absorbance 280nm:	998.57