General Information

  • ID:  hor000919
  • Uniprot ID:  NA
  • Protein name:  Leucosulfakinin-2
  • Gene name:  NA
  • Organism:  Rhyparobia maderae
  • Family:  Gastrin/cholecystokinin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  ESDDYGHMRF
  • Length:  10
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  The intestinal myotropic activity of leucosulfakinin-II is analogous to that of gastrin and cholecystokinin
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000919_AF2.pdbhor000919_ESM.pdb

Physical Information

Mass: 141702 Formula: C53H73N15O19S
Absent amino acids: ACIKLNPQTVW Common amino acids: D
pI: 4.37 Basic residues: 2
Polar residues: 3 Hydrophobic residues: 1
Hydrophobicity: -160 Boman Index: -4110
Half-Life: 1 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 1223 Extinction Coefficient cystines: 1490
Absorbance 280nm: 165.56

Literature

  • PubMed ID:  3778455
  • Title:  Leucosulfakinin-II, a Blocked Sulfated Insect Neuropeptide With Homology to Cholecystokinin and Gastrin