General Information

  • ID:  hor000908
  • Uniprot ID:  NA
  • Protein name:  Cholecystokinin 4
  • Gene name:  NA
  • Organism:  NA
  • Family:  Gastrin/cholecystokinin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  WMDF
  • Length:  4
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Have an insulinotropic effect
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: CCK tetrapeptide showed a half-life of 13 min in human plasma while its cleavage in rat plasma occurred at a very high rate (half-life of less than 1 min) ( PubMed ID: 6291099 )

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000908_AF2.pdbhor000908_ESM.pdb

Physical Information

Mass: 65138 Formula: C29H35N5O7S
Absent amino acids: ACEGHIKLNPQRSTVY Common amino acids: DFMW
pI: 3.75 Basic residues: 0
Polar residues: 0 Hydrophobic residues: 2
Hydrophobicity: 7.5 Boman Index: -106
Half-Life: 2.8 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 0
Instability Index: 4785 Extinction Coefficient cystines: 5500
Absorbance 280nm: 1833.33

Literature

  • PubMed ID:  11044801##6291099
  • Title:  Biological Effects of Newly Synthesized Cholecystokinin Analogs