HORDB

ID: hor000878
Uniprot ID: Q28470
Protein name: Endothelin-2
Gene name: EDN2
Organism: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Family: Endothelin/sarafotoxin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Macaca (genus), Cercopithecinae (subfamily), Cercopithecidae (family), Cercopithecoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0019229 regulation of vasoconstriction; GO:0042310 vasoconstriction; GO:0097746 blood vessel diameter maintenance
GO CC: GO:0005576 extracellular region

Sequence: PEQTAPYGLGNPPRRRRRSLPRRCQCSSARDPSCATFCLRRPWTEARAVPSRKSPADVFQTGKTGATRGELLQRLRDIS
Length: 79(1-79)
Propeptide: PEQTAPYGLGNPPRRRRRSLPRRCQCSSARDPSCATFCLRRPWTEARAVPSRKSPADVFQTGKTGATRGELLQRLRDIS
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q28470-F1.pdb

hor000878_AF2.pdb

hor000878_ESM.pdb

Mass:	1028753	Formula:	C376H622N132O111S4
Absent amino acids:	HM	Common amino acids:	R
pI:	11.93	Basic residues:	17
Polar residues:	24	Hydrophobic residues:	19
Hydrophobicity:	-99.11	Boman Index:	-27635
Half-Life:	>20 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	?	Aliphatic Index	50.76
Instability Index:	9708.48	Extinction Coefficient cystines:	7240
Absorbance 280nm:	92.82