HORDB

ID: hor000870
Uniprot ID: P19998
Protein name: Endothelin-3
Gene name: EDN3
Organism: Oryctolagus cuniculus (Rabbit)
Family: Endothelin/sarafotoxin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Oryctolagus (genus), Leporidae (family), Lagomorpha (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0019229 regulation of vasoconstriction; GO:0042310 vasoconstriction; GO:0097746 blood vessel diameter maintenance
GO CC: GO:0005576 extracellular region

Sequence: CTCFTYKDKECVYYCHLDIIW
Length: 21(89-109)
Propeptide: MEPGLWILLGLTVTAAAGFVPCPQTGGAGRTSVPRAPRVAGSEGDCEDSVASPRRQTVAPTAGKGPSPGSPGRGQAAEGDPGHRRVRRCTCFTYKDKECVYYCHLDIIWINTPE
Signal peptide: MEPGLWILLGLTVTAAA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000870_AF2.pdb

hor000870_ESM.pdb

Mass:	300403	Formula:	C121H172N26O33S4
Absent amino acids:	AGMNPQRS	Common amino acids:	C
pI:	5.51	Basic residues:	3
Polar residues:	9	Hydrophobic residues:	6
Hydrophobicity:	10	Boman Index:	-1634
Half-Life:	1.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	69.52
Instability Index:	5614.76	Extinction Coefficient cystines:	10220
Absorbance 280nm:	511