HORDB

ID: hor000858
Uniprot ID: Q5NRQ1
Protein name: Endothelin-1
Gene name: EDN1
Organism: Felis catus (Cat) (Felis silvestris catus)
Family: Endothelin/sarafotoxin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Felis (genus), Felinae (subfamily), Felidae (family), Feliformia (suborder), Carnivora (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0031707 endothelin A receptor binding; GO:0031708 endothelin B receptor binding
GO BP: GO:0003100 regulation of systemic arterial blood pressure by endothelin; GO:0006874 intracellular calcium ion homeostasis; GO:0014826 vein smooth muscle contraction; GO:0019229 regulation of vasoconstriction; GO:0042310 vasoconstriction; GO:0086100 endothelin receptor signaling pathway; GO:0097746 blood vessel diameter maintenance; GO:1900182 positive regulation of protein localization to nucleus
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: CSCSSLLDKECVYFCHLDIIW
Length: 21
Propeptide: MDYLPVLFSLLLVVFQGAPEAAVLGAELSTGPDSGGEKPAPSAPWRPRRSKRCSCSSLLDKECVYFCHLDIIWVNTPEHIVPYGLGSPSRSKRSLKDLFATKATDHRNRCQCASQKDKKCWTFCQVRKELRGQDSMEKGWDDQKKGKDCSELGEKCTHHQLVAGRKIRRLDAVRNSIKTAFRVAKLKAEIYREKKVTHNRTH
Signal peptide: MDYLPVLFSLLLVVFQGAPEAAVLG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: endothelium-derived vasoconstrictor peptides
Mechanism: activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells
Cross BBB: NA
Target: EDNRA, EDNRB
Target Unid: M3WMJ5, A0A337SDI4
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000858_AF2.pdb

hor000858_ESM.pdb

Mass:	283485	Formula:	C110H165N25O32S4
Absent amino acids:	AGMNPQRT	Common amino acids:	C
pI:	4.37	Basic residues:	2
Polar residues:	8	Hydrophobic residues:	8
Hydrophobicity:	72.38	Boman Index:	-573
Half-Life:	1.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	106.67
Instability Index:	5944.29	Extinction Coefficient cystines:	7240
Absorbance 280nm:	362