HORDB

ID: hor000849
Uniprot ID: Q5NRP9
Protein name: Endothelin-1
Gene name: EDN1
Organism: Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog)
Family: Endothelin/sarafotoxin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Atelerix (genus), Erinaceinae (subfamily), Erinaceidae (family), Eulipotyphla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0019229 regulation of vasoconstriction; GO:0042310 vasoconstriction; GO:0086100 endothelin receptor signaling pathway; GO:0097746 blood vessel diameter maintenance; GO:1900182 positive regulation of protein localization to nucleus
GO CC: GO:0005576 extracellular region

Sequence: CSCSSLMDKECVYFCHLDIIW
Length: 21
Propeptide: MDYFPMIFSLLFVAFHGAPETVVLGAELSTESEQGGEQPSPSPPWRPRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPLRSRRSLKNSFPTKAADHRNRCRCASQKDKKCWNFCQAGKGLRLQDTMEKDWNNQKKGKDCSKLGDKCIHQQLVEGRKIRRLEAISNSIKTSFHIAKLKAELYREKKVTHNGTH
Signal peptide: MDYFPMIFSLLFVAFHGAPETVVLG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: endothelium-derived vasoconstrictor peptides
Mechanism: activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells
Cross BBB: YES
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: 40 seconds; /40 seconds ( PubMed ID: 2182027 )

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000849_AF2.pdb

hor000849_ESM.pdb

Mass:	285288	Formula:	C109H163N25O32S5
Absent amino acids:	AGNPQRT	Common amino acids:	C
pI:	4.37	Basic residues:	2
Polar residues:	8	Hydrophobic residues:	7
Hydrophobicity:	63.33	Boman Index:	-830
Half-Life:	1.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	88.1
Instability Index:	5944.29	Extinction Coefficient cystines:	7240
Absorbance 280nm:	362