General Information

  • ID:  hor000846
  • Uniprot ID:  A0A6I8T5H9
  • Protein name:  Ecdysis triggering hormone-2b
  • Gene name:  5572299
  • Organism:  Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Stegomyia (subgenus), Aedes (genus), Aedini (tribe), Culicinae (subfamily), Culicidae (family), Culicoidea (superfamily), Culicomorpha (infraorder), Nematocera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  GDFENFFLKQSKSVPRI
  • Length:  17(38-54)
  • Propeptide:  MMKFILLLVALVTLAVADETPGFFIKLSKSVPRIGRRGDFENFFLKQSKSVPRIGRRSGLFTEHSPAQDNSNWFERFMRPAKRPISTPQTENGKLYSKVRPLDLHHIIDILSDDLFFGSDLKFISWDVLDEALEEDPELMGKLSALARDKEVHQLKQLLTENKDELVQYVPLESGTSDMHSNKAYIYRTDRDEQNAELNKEKIEYQQ
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A0A6I8T5H9-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000846_AF2.pdbhor000846_ESM.pdb

Physical Information

Mass: 229785 Formula: C93H142N24O26
Absent amino acids: ACHMTWY Common amino acids: F
pI: 9.53 Basic residues: 3
Polar residues: 4 Hydrophobic residues: 6
Hydrophobicity: -52.94 Boman Index: -3677
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 62.94
Instability Index: 3781.18 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  20163154
  • Title:  Neuropeptidomics of the Mosquito Aedes Aegypti