HORDB

ID: hor000830
Uniprot ID: Q9GSA4
Protein name: Corazonin precursor-related peptide
Gene name: crz
Organism: Galleria mellonella (Greater wax moth)
Family: Corazonin family
Source: Animal
Expression: Four pairs of lateral neurosecretory cells in the brains of late instar larvae, pupae and adults.
Disease: NA
Comments: NA
Taxonomy: Galleria (genus), Galleriinae (subfamily), Pyralidae (family), Pyraloidea (superfamily), Obtectomera, Ditrysia, Heteroneura (parvorder), Neolepidoptera (infraorder), Glossata (suborder), Lepidoptera (order), Amphiesmenoptera (superorder), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005184 neuropeptide hormone activity; GO:0071858 corazonin receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0045823 positive regulation of heart contraction
GO CC: GO:0005576 extracellular region

Sequence: DGHKTEDIRDLTNNLERILSPCQMNKLKYVLEGKPLNERLLGPCDTSKTRSTTNPSDTNTSAVKTPCSTHFNKHCYSFSY
Length: 80(34-113)
Propeptide: MATNITMFLIVITLTSVAAQTFQYSRGWTNGKRDGHKTEDIRDLTNNLERILSPCQMNKLKYVLEGKPLNERLLGPCDTSKTRSTTNPSDTNTSAVKTPCSTHFNKHCYSFSY
Signal peptide: MATNITMFLIVITLTSVAA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000830_AF2.pdb

hor000830_ESM.pdb

Mass:	1047241	Formula:	C387H619N113O128S5
Absent amino acids:	W	Common amino acids:	T
pI:	8.33	Basic residues:	14
Polar residues:	35	Hydrophobic residues:	15
Hydrophobicity:	-92.25	Boman Index:	-21335
Half-Life / Aliphatic Index:	1.1 hour	Aliphatic Index:	57.25
Instability Index:	2141	Extinction Coefficient cystines:	4720
Absorbance 280nm:	59.75