HORDB

ID: hor000719
Uniprot ID: Q75UG5
Protein name: Cardioactive peptide
Gene name: CCAP
Organism: Periplaneta americana (American cockroach) (Blatta americana)
Family: NA
Source: animal
Expression: Central nervous system; most neurons exhibit coexpression with burs.
Disease: NA
Comments: NA
Taxonomy: Periplaneta (genus), Blattinae (subfamily), Blattidae (family), Blattoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: PFCNAFTGC
Length: 9
Propeptide: MQMYHVVLGCSLAILLVILDIPQASCDDVVIQKRQVDPAEMDRLLDPKRKRPFCNAFTGCGKKRSDESMGTLVEMNSEPAVDDLSRQILSEVKLWEAIQEARVELLRRRQEQLQQQSNQFGAGMDRPLPLPIAGYRRKRFADPESQAPAPHSNLPRATSQLQEEITKPWSR
Signal peptide: MQMYHVVLGCSLAILLVILDIPQASC
Modification: T9 Cysteine amide
Glycosylation: NA
Mutagenesis: NA

Function: Cardioregulatory neurohormone that increases heart beat rate during adult wing inflation; has no effect on beat amplitude. The effect of CCAP is both ino- and chronotropic
Mechanism: NA
Cross BBB: NO
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000719_AF2.pdb

hor000719_ESM.pdb

Mass:	110198	Formula:	C42H58N10O12S2
Absent amino acids:	DEHIKLMQRSVWY	Common amino acids:	CF
pI:	5.84	Basic residues:	0
Polar residues:	5	Hydrophobic residues:	3
Hydrophobicity:	68.89	Boman Index:	206
Half-Life:	>20 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	?	Aliphatic Index	11.11
Instability Index:	2085.56	Extinction Coefficient cystines:	125
Absorbance 280nm:	15.63