General Information

  • ID:  hor000683
  • Uniprot ID:  P06881
  • Protein name:  Calcitonin gene-related peptide 1
  • Gene name:  CALCA
  • Organism:  Homo sapiens (Human)
  • Family:  Calcitonin family
  • Source:  Human
  • Expression:  NA
  • Disease:  Diseases associated with CALCA include Reflex Sympathetic Dystrophy and Complex Regional Pain Syndrome.
  • Comments:  NA
  • Taxonomy:  Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005102 signaling receptor binding; GO:0005179 hormone activity; GO:0005515 protein binding; GO:0044877 protein-containing complex binding
  • GO BP:  GO:0001935 endothelial cell proliferation; GO:0001944 vasculature development; GO:0002031 G protein-coupled receptor internalization; GO:0006468 protein phosphorylation; GO:0007159 leukocyte cell-cell adhesion; GO:0007165 signal transduction; GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway; GO:0007190 activation of adenylate cyclase activity; GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway; GO:0007267 cell-cell signaling; GO:0008217 regulation of blood pressure; GO:0010523 negative regulation of calcium ion transport into cytosol; GO:0031623 receptor internalization; GO:0032730 positive regulation of interleukin-1 alpha production; GO:0032757 positive regulation of interleukin-8 production; GO:0042311 vasodilation; GO:0043542 endothelial cell migration; GO:0045651 positive regulation of macrophage differentiation; GO:0045671 negative regulation of osteoclast differentiation; GO:0045779 negative regulation of bone resorption; GO:0051480 regulation of cytosolic calcium ion concentration; GO:1990408 calcitonin gene-related peptide receptor signaling pathway
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005737 cytoplasm

Sequence Information

  • Sequence:  ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF
  • Length:  37(83-119)
  • Propeptide:  MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQMKASELEQEQEREGSRIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFGRRRRDLQA
  • Signal peptide:  MGFQKFSPFLALSILVLLQAGSLHA
  • Modification:  T37 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  RAMP1, CALCRL
  • Target Unid:  O60894, Q16602
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: 414 seconds ( PubMed ID: 3922013 )

Structure

  • Disulfide bond:  45695
  • Structure ID:  AF-P06881-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000683_AF2.pdbhor000683_ESM.pdb

Physical Information

Mass: 443466 Formula: C163H268N50O50S2
Absent amino acids: EIMQWY Common amino acids: V
pI: 9.76 Basic residues: 5
Polar residues: 16 Hydrophobic residues: 14
Hydrophobicity: 21.08 Boman Index: -4024
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 81.62
Instability Index: 3284.05 Extinction Coefficient cystines: 125
Absorbance 280nm: 3.47

Literature

  • PubMed ID:  6609312##3922013
  • Title:  Isolation and Characterization of Human Calcitonin Gene-Related Peptide