General Information

  • ID:  hor000671
  • Uniprot ID:  B3IWF8
  • Protein name:  Calcitonin receptor-stimulating peptide 2
  • Gene name:  CRSP2
  • Organism:  Capra hircus (Goat)
  • Family:  Calcitonin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Capra (genus), Caprinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SCNRATCVTHKMAGSLSRSGSEIKRNFMSTNVGSKAFGQRSRDLQK
  • Length:  46
  • Propeptide:  MGFWKFLPFLVLSFLVVYQAGMFQAAPFRSALENDFDPAILTEKEMCLLLAAVMNDYVQMKTSELKQEAEHFHITAQKRSCNRATCVTHKMAGSLSRSGSEIKRNFMSTNVGSKAFGQRSRDLQK
  • Signal peptide:  MGFWKFLPFLVLSFLVVYQAGMFQA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  2-7
  • Structure ID:  AF-B3IWF8-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000671_AF2.pdbhor000671_ESM.pdb

Physical Information

Mass: 583652 Formula: C206H348N72O67S4
Absent amino acids: PWY Common amino acids: S
pI: 11.6 Basic residues: 10
Polar residues: 20 Hydrophobic residues: 10
Hydrophobicity: -77.39 Boman Index: -13765
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 44.57
Instability Index: 8033.7 Extinction Coefficient cystines: 125
Absorbance 280nm: 2.78

Literature

  • PubMed ID:  NA
  • Title:  Identification and biological activity of ovine and caprine calcitonin receptor-Sti.