General Information

  • ID:  hor000653
  • Uniprot ID:  P85824
  • Protein name:  Allatostatin-3
  • Gene name:  NA
  • Organism:  Rhodnius prolixus (Triatomid bug)
  • Family:  Allatostatin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Rhodnius (genus), Triatominae (subfamily), Reduviidae (family), Reduvioidea (superfamily), Cimicomorpha (infraorder), Panheteroptera, Neoheteroptera, Euheteroptera, Heteroptera (suborder), Prosorrhyncha, Hemiptera (order), Paraneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QVSLKYPEGKMYSFGL
  • Length:  16(1-16)
  • Propeptide:  QVSLKYPEGKMYSFGL
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T16 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May act as a neurotransmitter or neuromodulator
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P85824-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    AF-P85824-F1.pdbhor000653_AF2.pdbhor000653_ESM.pdb

Physical Information

Mass: 211488 Formula: C86H131N19O24S
Absent amino acids: ACDHINRTW Common amino acids: GKLSY
pI: 9.12 Basic residues: 2
Polar residues: 6 Hydrophobic residues: 4
Hydrophobicity: -30.63 Boman Index: -944
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 66.88
Instability Index: 4780 Extinction Coefficient cystines: 2980
Absorbance 280nm: 198.67

Literature

  • PubMed ID:  19137558
  • Title:  The Neuropeptidome of Rhodnius Prolixus Brain