General Information

  • ID:  hor000590
  • Uniprot ID:  P41841
  • Protein name:  Callatostatin-5
  • Gene name:  NA
  • Organism:  Calliphora vomitoria (Blue bottle fly) (Musca vomitoria)
  • Family:  Allatostatin family
  • Source:  Animal
  • Expression:  Neurons within brain and abdominal ganglion.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Calliphora (genus), Calliphorinae (subfamily), Calliphoridae (family), Oestroidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GPPYDFGM
  • Length:  8(1-8)
  • Propeptide:  GPPYDFGM
  • Signal peptide:  NA
  • Modification:  T3 Hydroxyproline;T8 Methionine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  inhibit juvenile hormone production
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000590_AF2.pdbhor000590_ESM.pdb

Physical Information

Mass: 100802 Formula: C41H54N8O12S
Absent amino acids: ACEHIKLNQRSTVW Common amino acids: GP
pI: 3.75 Basic residues: 0
Polar residues: 3 Hydrophobic residues: 1
Hydrophobicity: -51.25 Boman Index: -165
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 5300 Extinction Coefficient cystines: 1490
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  8460157
  • Title:  Callatostatins: Neuropeptides From the Blowfly Calliphora Vomitoria With Sequence Homology to Cockroach Allatostatins