General Information

  • ID:  hor000537
  • Uniprot ID:  A0A921Z0J2
  • Protein name:  MIP VI
  • Gene name:  NA
  • Organism:  Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
  • Family:  Allatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Manduca (genus), Sphingini (tribe), Sphinginae (subfamily), Sphingidae (family), Bombycoidea (superfamily), Obtectomera, Ditrysia, Heteroneura (parvorder), Neolepidoptera (infraorder), Glossata (suborder), Lepidoptera (order), Amphiesmenoptera (superorder), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  AWSALHGAW
  • Length:  9(245-253)
  • Propeptide:  MRCCVAVLWAFFATWAVAAAEEPHHDAAPQTDNELDLTDEDKRAWTSLRGGWAKRGWQDMSSAWGKRAWQDLNSAWGKRAWQDLNSAWGKRAWQDLNSAWGKRGWQDLNSAWGKRSDDEAMDKRAWQDLNSAWGKRGWQDMSSAWGKRAWQDLNSAWGKRGWNDMSSAWGKRAWQDLNSAWGKRGWQDMSSAWGKRAPEKWAAFHGSWGKRAAEPDYEELDAAIEQLVPIHQMDEDRMDAPEKKAWSALHGAWGK
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000537_AF2.pdbhor000537_ESM.pdb

Physical Information

Mass: 114100 Formula: C48H63N13O11
Absent amino acids: CDEFIKMNPQRTVY Common amino acids: A
pI: 7.55 Basic residues: 1
Polar residues: 2 Hydrophobic residues: 6
Hydrophobicity: 33.33 Boman Index: 789
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 76.67
Instability Index: -1206.67 Extinction Coefficient cystines: 11000
Absorbance 280nm: 1375

Literature

  • PubMed ID:  14599724
  • Title:  A Comparison of the Neuropeptides From the Retrocerebral Complex of Adult Male and Female Manduca Sexta Using MALDI-TOF Mass Spectrometry