General Information

  • ID:  hor000535
  • Uniprot ID:  A0A921Z0J2
  • Protein name:  MIP III
  • Gene name:  NA
  • Organism:  Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
  • Family:  Allatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Manduca (genus), Sphingini (tribe), Sphinginae (subfamily), Sphingidae (family), Bombycoidea (superfamily), Obtectomera, Ditrysia, Heteroneura (parvorder), Neolepidoptera (infraorder), Glossata (suborder), Lepidoptera (order), Amphiesmenoptera (superorder), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  APEKWAAFHGSW
  • Length:  12(197-208)
  • Propeptide:  MRCCVAVLWAFFATWAVAAAEEPHHDAAPQTDNELDLTDEDKRAWTSLRGGWAKRGWQDMSSAWGKRAWQDLNSAWGKRAWQDLNSAWGKRAWQDLNSAWGKRGWQDLNSAWGKRSDDEAMDKRAWQDLNSAWGKRGWQDMSSAWGKRAWQDLNSAWGKRGWNDMSSAWGKRAWQDLNSAWGKRGWQDMSSAWGKRAPEKWAAFHGSWGKRAAEPDYEELDAAIEQLVPIHQMDEDRMDAPEKKAWSALHGAWGK
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000535_AF2.pdbhor000535_ESM.pdb

Physical Information

Mass: 158292 Formula: C67H87N17O16
Absent amino acids: CDILMNQRTVY Common amino acids: A
pI: 7.55 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 6
Hydrophobicity: -58.33 Boman Index: -641
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 25
Instability Index: 1853.33 Extinction Coefficient cystines: 11000
Absorbance 280nm: 1000

Literature

  • PubMed ID:  14599724
  • Title:  A Comparison of the Neuropeptides From the Retrocerebral Complex of Adult Male and Female Manduca Sexta Using MALDI-TOF Mass Spectrometry