General Information

  • ID:  hor000534
  • Uniprot ID:  A0A921Z0J2
  • Protein name:  Mas-MIP1
  • Gene name:  NA
  • Organism:  Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
  • Family:  Allatostatin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Manduca (genus), Sphingini (tribe), Sphinginae (subfamily), Sphingidae (family), Bombycoidea (superfamily), Obtectomera, Ditrysia, Heteroneura (parvorder), Neolepidoptera (infraorder), Glossata (suborder), Lepidoptera (order), Amphiesmenoptera (superorder), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  AWQDLNSAW
  • Length:  9(68-76)
  • Propeptide:  MRCCVAVLWAFFATWAVAAAEEPHHDAAPQTDNELDLTDEDKRAWTSLRGGWAKRGWQDMSSAWGKRAWQDLNSAWGKRAWQDLNSAWGKRAWQDLNSAWGKRGWQDLNSAWGKRSDDEAMDKRAWQDLNSAWGKRGWQDMSSAWGKRAWQDLNSAWGKRGWNDMSSAWGKRAWQDLNSAWGKRGWQDMSSAWGKRAPEKWAAFHGSWGKRAAEPDYEELDAAIEQLVPIHQMDEDRMDAPEKKAWSALHGAWGK
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Metamorphosis and muscle contractions
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000534_AF2.pdbhor000534_ESM.pdb

Physical Information

Mass: 123305 Formula: C50H67N13O15
Absent amino acids: CEFGHIKMPRTVY Common amino acids: AW
pI: 3.75 Basic residues: 0
Polar residues: 2 Hydrophobic residues: 5
Hydrophobicity: -63.33 Boman Index: -1110
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 65.56
Instability Index: 2928.89 Extinction Coefficient cystines: 11000
Absorbance 280nm: 1375

Literature

  • PubMed ID:  16061202
  • Title:  Discovering Neuropeptides in Caenorhabditis Elegans by Two Dimensional Liquid Chromatography and Mass Spectrometry