General Information

  • ID:  hor000303
  • Uniprot ID:  NA
  • Protein name:  Allatostatin A
  • Gene name:  NA
  • Organism:  Ascaris suum
  • Family:  Allatostatin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  GDGRLYAFGL
  • Length:  10
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T10 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Exhibited significant inhibitory effects on ovijector at 10 microM
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000303_AF2.pdbhor000303_ESM.pdb

Physical Information

Mass: 122892 Formula: C49H73N13O14
Absent amino acids: CEHIKMNPQSTVW Common amino acids: G
pI: 6.34 Basic residues: 1
Polar residues: 4 Hydrophobic residues: 4
Hydrophobicity: 17 Boman Index: -633
Half-Life / Aliphatic Index: 30 hour Aliphatic Index: 88
Instability Index: 3268 Extinction Coefficient cystines: 1490
Absorbance 280nm: 165.56

Literature

  • PubMed ID:  16185693
  • Title:  Expression and Bioactivity of Allatostatin-Like Neuropeptides in Helminths