General Information

  • ID:  hor000287
  • Uniprot ID:  NA
  • Protein name:  Bradykinin
  • Gene name:  NA
  • Organism:  Bovine
  • Family:  Bradykinin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  RPPGFSPFG
  • Length:  9
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  An inhibitor of thrombin’s roles in blood clotting, platelet activation, and cellular permeability
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000287_AF2.pdbhor000287_ESM.pdb

Physical Information

Mass: 110394 Formula: C46H64N12O11
Absent amino acids: ACDEHIKLMNQTVWY Common amino acids: P
pI: 10.55 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 2
Hydrophobicity: -58.89 Boman Index: -1048
Half-Life: 1 hour Half-Life Yeast: 2 min
Half-Life E.Coli: 2 min Aliphatic Index 0
Instability Index: 12191.11 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  12559981
  • Title:  Establishing the Inhibitory Effects of Bradykinin on Thrombin