HORDB

General Information

ID: hor000286
Uniprot ID: NA
Protein name: Bradykinin
Gene name: NA
Organism: Leucoraja erinacea
Family: Bradykinin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: NA
GO MF: NA
GO BP: NA
GO CC: NA

Sequence Information

Sequence: GITSWLPF
Length: 8
Propeptide: NA
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Activity

Function: Constriction of the mesenteric artery;constriction of intestinal smooth muscle
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: mesenteric artery: 4.37*10(-8)M;intestinal smooth muscle: 2.74*10(-7)M
ED50: NA
kd: NA
Half life: NA

Structure

Disulfide bond: NA
Structure ID: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000286_AF2.pdb

hor000286_ESM.pdb

Physical Information

Mass:	104511	Formula:	C46H65N9O11
Absent amino acids:	ACDEHKMNQRVY	Common amino acids:	FGILPSTW
pI:	6.11	Basic residues:	0
Polar residues:	3	Hydrophobic residues:	4
Hydrophobicity:	83.75	Boman Index:	1012
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	97.5
Instability Index:	6171.25	Extinction Coefficient cystines:	5500
Absorbance 280nm:	785.71

Literature

PubMed ID: 18502540
Title: Purification, Structural Characterization, and Myotropic Activity of a Peptide Related to des-Arg(9)-bradykinin From an Elasmobranch Fish, the Little Skate, Leucoraja Erinacea