General Information

  • ID:  hor000259
  • Uniprot ID:  NA
  • Protein name:  Bombesin-like peptide
  • Gene name:  NA
  • Organism:  Canine
  • Family:  Bombesin/neuromedin-B/ranatensin family
  • Source:  animal
  • Expression:  intestinal muscle
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  APVPGGQGTVLDKMYPRGNHWAVGHLM
  • Length:  27
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Modulates a variety of biological activities in the gastrointestinal tract and the central nervous system.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000259_AF2.pdbhor000259_ESM.pdb

Physical Information

Mass: 335330 Formula: C129H198N38O34S2
Absent amino acids: CEFIS Common amino acids: G
pI: 9.3 Basic residues: 4
Polar residues: 8 Hydrophobic residues: 8
Hydrophobicity: -27.41 Boman Index: -1609
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 68.52
Instability Index: 3586.67 Extinction Coefficient cystines: 6990
Absorbance 280nm: 268.85

Literature

  • PubMed ID:  6853532
  • Title:  Amino Acid Sequences of Three Bombesin-Like Peptides From Canine Intestine Extracts