General Information

  • ID:  hor000151
  • Uniprot ID:  Q2L9W6
  • Protein name:  CPRP[1-12]
  • Gene name:  chh
  • Organism:  Callinectes sapidus (Blue crab)
  • Family:  Arthropod CHH/MIH/GIH/VIH hormone family
  • Source:  animal
  • Expression:  sinus gland
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Callinectes (genus), Portuninae (subfamily), Portunidae (family), Portunoidea (superfamily), Heterotremata, Eubrachyura, Brachyura (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  RSAEGLGRMGRL
  • Length:  12
  • Propeptide:  MQSIKTVCQITLLVTCMMATLSYTHARSAEGLGRMGRLLASLKSDTVTPLRGFEGETGHPLEKRQIYDSSCKGVYDRAIFNELEHVCDDCYNLYRNSRVASGCRENCFDNMMFETCVQELFYPEDMLLVRDAIRG
  • Signal peptide:  MQSIKTVCQITLLVTCMMATLSYTHA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q2L9W6-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000151_AF2.pdbhor000151_ESM.pdb

Physical Information

Mass: 149890 Formula: C52H95N21O16S
Absent amino acids: CDFHIKNPQTVWY Common amino acids: GR
pI: 12.2 Basic residues: 3
Polar residues: 4 Hydrophobic residues: 3
Hydrophobicity: -64.17 Boman Index: -3815
Half-Life: 1 hour Half-Life Yeast: 2 min
Half-Life E.Coli: 2 min Aliphatic Index 73.33
Instability Index: 4578.33 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  21740068
  • Title:  Discovery and Characterization of the Crustacean Hyperglycemic Hormone Precursor Related Peptides (CPRP) and Orcokinin Neuropeptides in the Sinus Glands of the Blue Crab?Callinectes sapidus?Using Multiple Tandem Mass Spectrometry Techniques