General Information

  • ID:  hor000134
  • Uniprot ID:  P23435
  • Protein name:  Cerebellin
  • Gene name:  CBLN1
  • Organism:  Homo sapiens (Human)
  • Family:  Cerebellins family
  • Source:  Human
  • Expression:  Low at birth, the cerebellin concentration increases between day 5 and 15, and reaches peak values between day 21 and 56.|In the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des-Ser1]-cerebellin.
  • Disease:  Diseases associated with CBLN1 include Postsurgical Hypothyroidism.
  • Comments:  NA
  • Taxonomy:  Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005515 protein binding; GO:0042802 identical protein binding
  • GO BP:  GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; GO:0007268 chemical synaptic transmission; GO:0007399 nervous system development; GO:0007416 synapse assembly; GO:0009306 protein secretion; GO:0021707 cerebellar granule cell differentiation; GO:0050808 synapse organization; GO:0051649 establishment of localization in cell; GO:0051965 positive regulation of synapse assembly; GO:0090394 negative regulation of excitatory postsynaptic potential; GO:0099151 regulation of postsynaptic density assembly; GO:0099558 maintenance of synapse structure; GO:1900454 positive regulation of long-term synaptic depression; GO:1905606 regulation of presynapse assembly; GO:1905703 negative regulation of inhibitory synapse assembly
  • GO CC:  GO:0005576 extracellular region; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0043083 synaptic cleft; GO:0045202 synapse; GO:0045211 postsynaptic membrane; GO:0062023 collagen-containing extracellular matrix; GO:0098688 parallel fiber to Purkinje cell synapse; GO:0098978 glutamatergic synapse

Sequence Information

  • Sequence:  SGSAKVAFSAIRSTNH
  • Length:  16
  • Propeptide:  MLGVLELLLLGAAWLAGPARGQNETEPIVLEGKCLVVCDSNPTSDPTGTALGISVRSGSAKVAFSAIRSTNHEPSEMSNRTMIIYFDQVLVNIGNNFDSERSTFIAPRKGIYSFNFHVVKVYNRQTIQVSLMLNGWPVISAFAGDQDVTREAASNGVLIQMEKGDRAYLKLERGNLMGGWKYSTFSGFLVFPL
  • Signal peptide:  MLGVLELLLLGAAWLAGPARG
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Exerts neuromodulatory functions
  • Mechanism:  Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9R0R3-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-Q9R0R3-F1.pdbhor000134_AF2.pdbhor000134_ESM.pdb

Physical Information

Mass: 190052 Formula: C69H113N23O23
Absent amino acids: CDELMPQWY Common amino acids: S
pI: 11.65 Basic residues: 3
Polar residues: 7 Hydrophobic residues: 6
Hydrophobicity: -15.63 Boman Index: -2963
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 61.25
Instability Index: 2213.75 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  2760624
  • Title:  Purification and Characterisation of Cerebellins From Human and Porcine Cerebellum