HORDB

ID: hor000113
Uniprot ID: P09892
Protein name: Small cardioactive peptide B
Gene name: NA
Organism: Aplysia californica (California sea hare)
Family: SCP family
Source: animal
Expression: Highly expressed in the buccal ganglion.
Disease: NA
Comments: NA
Taxonomy: Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: MNYLAFPRM
Length: 9
Propeptide: METSVSRVTVSLTLLVLIICSADAMNYLAFPRMGRARPGYLAFPRMGRSQMKTETGTDCCGLGMKSEFVIGQEGKEELRHGACSSSVACCAGLREIVDQKQDGVFFSMCVPDFVASRSSEESSSEVLSKLKSLLQK
Signal peptide: METSVSRVTVSLTLLVLIICSADA
Modification: T9 Methionine amide
Glycosylation: NA
Mutagenesis: NA

Function: Stimulate contractile activity in the gut; increasing the amplitude of the heart beat, and enhancing the contractile response of the radula closer muscle
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000113_AF2.pdb

hor000113_ESM.pdb

Mass:	128527	Formula:	C52H79N13O12S2
Absent amino acids:	CDEGHIKQSTVW	Common amino acids:	M
pI:	9.35	Basic residues:	1
Polar residues:	2	Hydrophobic residues:	3
Hydrophobicity:	14.44	Boman Index:	-729
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	54.44
Instability Index:	2191.11	Extinction Coefficient cystines:	1490
Absorbance 280nm:	186.25

PubMed ID: 3858852
Title: The Small Cardioactive Peptides A and B of Aplysia Are Derived From a Common Precursor Molecule