HORDB

ID: hor000067
Uniprot ID: P08162
Protein name: Mesotocin
Gene name: NA
Organism: Bufo japonicus (Japanese toad)
Family: Vasopressin/oxytocin family
Source: Animal
Expression: Mesotocin is produced by magnocellular preoptic neurons in the hypothalamus in amphibians, reptiles and birds.
Disease: NA
Comments: NA
Taxonomy: Bufo (genus), Bufonidae (family), Hyloidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005185 neurohypophyseal hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Sequence: CYIQNCPIG
Length: 9(20-28)
Propeptide: MSYTALAVTFFGWLALSSACYIQNCPIGGKRSVIDFMDVRKCIPCGPRNKGHCFGPNICCGEELGCYFGTTETLRCQEENFLPSPCESGRKPCGNNGGNCARSGICCNHESCTMDPACEQDSVFS
Signal peptide: MSYTALAVTFFGWLALSSA
Modification: T9 Glycine amide
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000067_AF2.pdb

hor000067_ESM.pdb

Mass:	115308	Formula:	C43H67N11O13S2
Absent amino acids:	ADEFHKLMRSTVW	Common amino acids:	CI
pI:	5.81	Basic residues:	0
Polar residues:	5	Hydrophobic residues:	2
Hydrophobicity:	41.11	Boman Index:	102
Half-Life:	1.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	86.67
Instability Index:	2708.89	Extinction Coefficient cystines:	1615
Absorbance 280nm:	201.88

PubMed ID: 3033676
Title: Cloning and Sequence Analysis of cDNAs for Neurohypophysial Hormones Vasotocin and Mesotocin for the Hypothalamus of Toad, Bufo Japonicus