General Information

  • ID:  hor000063
  • Uniprot ID:  NA
  • Protein name:  Inotocin
  • Gene name:  NA
  • Organism:  Nasonia vitripennis
  • Family:  Vasopressin/oxytocin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  CLITNCPRL
  • Length:  9
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T9 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Plays a crucial role in regulation of urine production in the kidney
  • Mechanism:  AVP induces hyperpolarization through an apical V1 receptor
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000063_AF2.pdbhor000063_ESM.pdb

Physical Information

Mass: 117517 Formula: C43H77N13O12S2
Absent amino acids: ADEFGHKMQSVWY Common amino acids: CL
pI: 8.23 Basic residues: 1
Polar residues: 4 Hydrophobic residues: 3
Hydrophobicity: 75.56 Boman Index: -681
Half-Life / Aliphatic Index: 1.2 hour Aliphatic Index: 130
Instability Index: 2341.11 Extinction Coefficient cystines: 125
Absorbance 280nm: 15.63

Literature

  • PubMed ID:  20695486
  • Title:  Genomics and Peptidomics of Neuropeptides and Protein Hormones Present in the Parasitic Wasp Nasonia Vitripennis