General Information

  • ID:  hor000060
  • Uniprot ID:  NA
  • Protein name:  Arginine vasopressin
  • Gene name:  NA
  • Organism:  Rattus norvegicus (Rat)
  • Family:  Vasopressin/oxytocin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  ENCCPRG
  • Length:  7
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Improves spatial memory
  • Mechanism:  NC-1900 activates the V1A receptors in postsynaptic cholinergic nerve terminals, and leads to a transient influx of intracellular Ca2+ through L-type Ca2+ channels, resulting in an interaction with the M1 receptor.
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000060_AF2.pdbhor000060_ESM.pdb

Physical Information

Mass: 88507 Formula: C28H47N11O11S2
Absent amino acids: ADFHIKLMQSTVWY Common amino acids: C
pI: 6.14 Basic residues: 1
Polar residues: 4 Hydrophobic residues: 0
Hydrophobicity: -121.43 Boman Index: -2487
Half-Life: 1 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 907.14 Extinction Coefficient cystines: 125
Absorbance 280nm: 20.83

Literature

  • PubMed ID:  11553362
  • Title:  Ameliorative Effect of vasopressin-(4-9) Through Vasopressin V(1A) Receptor on Scopolamine-Induced Impairments of Rat Spatial Memory in the Eight-Arm Radial Maze