General Information

  • ID:  hor000058
  • Uniprot ID:  Q9QZQ4
  • Protein name:  Urotensin II
  • Gene name:  UTS2
  • Organism:  Rattus norvegicus (Rat)
  • Family:  Urotensin-2 family
  • Source:  Animal
  • Expression:  Brain specific.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Rattus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0001666 response to hypoxia; GO:0003105 negative regulation of glomerular filtration; GO:0007165 signal transduction; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0008217 regulation of blood pressure; GO:0009410 response to xenobiotic stimulus; GO:0010459 negative regulation of heart rate; GO:0010460 positive regulation of heart rate; GO:0010763 positive regulation of fibroblast migration; GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness; GO:0032224 positive regulation of synaptic transmission, cholinergic; GO:0032967 positive regulation of collagen biosynthetic process; GO:0033574 response to testosterone; GO:0035811 negative regulation of urine volume; GO:0045597 positive regulation of cell differentiation; GO:0045766 positive regulation of angiogenesis; GO:0045776 negative regulation of blood pressure; GO:0045777 positive regulation of blood pressure
  • GO CC:  NA

Sequence Information

  • Sequence:  QHGTAPECFWKYCI
  • Length:  14(110-123)
  • Propeptide:  MDRVPFCCLLFVGLLNPLLSFPVTDTGEMSLQLPVLEENALRALEELERTALLQTLRQTVGTEAEGSLGQADPSAETPTPRGSLRKALTGQDSNTVLSRLLARTRKQRKQHGTAPECFWKYCI
  • Signal peptide:  MDRVPFCCLLFVGLLNPLLS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Highly potent vasoconstrictor
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  Uts2r, Uts2b
  • Target Unid:  P49684, Q765I2
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  45882
  • Structure ID:  AF-Q9QZQ4-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000058_AF2.pdbhor000058_ESM.pdb

Physical Information

Mass: 191500 Formula: C77H107N19O20S2
Absent amino acids: DLMNRSV Common amino acids: C
pI: 7.25 Basic residues: 2
Polar residues: 5 Hydrophobic residues: 4
Hydrophobicity: -35 Boman Index: -973
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 35
Instability Index: 5337.14 Extinction Coefficient cystines: 7115
Absorbance 280nm: 547.31

Literature

  • PubMed ID:  17089015
  • Title:  Urotensin-II and Its Receptor (UT-R) Are Expressed in Rat Brain Endothelial Cells, and urotensin-II via UT-R Stimulates Angiogenesis in Vivo and in Vitro