HORDB

General Information

ID: hor000057
Uniprot ID: Q9QZQ3
Protein name: Urotensin II
Gene name: UTS2
Organism: Mus musculus (Mouse)
Family: Urotensin-2 family
Source: animal
Expression: Brain specific. Predominantly expressed in motoneurons of the brainstem and spinal cord.
Disease: NA
Comments: NA
Taxonomy: Mus (subgenus), Mus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0001666 response to hypoxia; GO:0003105 negative regulation of glomerular filtration; GO:0007165 signal transduction; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0008217 regulation of blood pressure; GO:0009410 response to xenobiotic stimulus; GO:0010459 negative regulation of heart rate; GO:0010460 positive regulation of heart rate; GO:0010763 positive regulation of fibroblast migration; GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness; GO:0032224 positive regulation of synaptic transmission, cholinergic; GO:0032967 positive regulation of collagen biosynthetic process; GO:0033574 response to testosterone
GO CC: NA

Sequence Information

Sequence: QHGAAPECFWKYCI
Length: 14
Propeptide: MDRVPFCCLLFIGLLNPLLSLPVTDTGERTLQLPVLEEDALRALEELERMALLQTLRQTMGTEAGESPGEAGPSTETPTPRGSMRKAFAGQNSNTVLSRLLARTRKQHKQHGAAPECFWKYCI
Signal peptide: MDRVPFCCLLFIGLLNPLLS
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Activity

Function: Be involved in some aspects of anxiety, depressive, and ingestive disorders;induces mice skeletal muscle atrophy associated with enhanced skeletal muscle autophagy and inhibited FNDC5 expression in chronic renal failure;highly potent vasoconstrictor;induces mice skeletal muscle atrophy associated with enhanced skeletal muscle autophagy and inhibited FNDC5 expression in chronic renal failure; modulates cholesterol regulation
Mechanism: U-II-induced vasoconstriction is attenuated by inhibition of phospholipase C-mediated [Ca2+]i-mobilization from the sarcoplasmic reticulum (leading to a secondary membrane depolarization and [Ca2+]i-influx) and by L-type [Ca2+]-channel blockers, calmodulin antagonism and by chelation of extracellular [Ca2+]e.
Cross BBB: NA
Target: Uts2r, Uts2b
Target Unid: Q8VIH9, Q765I1
IC50: NA
EC50: intracellular [Ca2+] concentrations:3.2+/-0.8nm;inositol phosphate (Ip) formation:7.2+/-1.8nm
ED50: NA
kd: NA
Half life: NA

Structure

Disulfide bond: 8-13
Structure ID: AF-Q9QZQ3-F1(AlphaFold_DB_ID)

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000057_AF2.pdb

hor000057_ESM.pdb

Physical Information

Mass:	188498	Formula:	C76H105N19O19S2
Absent amino acids:	DLMNRSTV	Common amino acids:	AC
pI:	7.25	Basic residues:	2
Polar residues:	4	Hydrophobic residues:	5
Hydrophobicity:	-17.14	Boman Index:	-535
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	42.14
Instability Index:	5337.14	Extinction Coefficient cystines:	7115
Absorbance 280nm:	547.31

Literature

PubMed ID: 16160878
Title: Behavioral Effects of urotensin-II Centrally Administered in Mice.
PubMed ID: 11976263
Title: Molecular and pharmacological characterization of genes encoding urotensin-II peptides and their cognate G-protein-coupled receptors from the mouse and monkey
PubMed ID: 31238319
Title: Urotensin II Induces Mice Skeletal Muscle Atrophy Associated With Enhanced Autophagy and Inhibited Irisin Precursor (Fibronectin Type III Domain Containing 5) Expression in Chronic Renal Failure