General Information

  • ID:  hor000054
  • Uniprot ID:  NA
  • Protein name:  Urotensin II
  • Gene name:  UTS2
  • Organism:  porcine
  • Family:  Urotensin-2 family
  • Source:  animal
  • Expression:  spinal cord
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  GPTSECFWKYCV
  • Length:  12
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  evoked a release of arachidonic acid metabolites
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: 1 nM
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000054_AF2.pdbhor000054_ESM.pdb

Physical Information

Mass: 161601 Formula: C65H90N14O18S2
Absent amino acids: ADHILMNQR Common amino acids: C
pI: 6.13 Basic residues: 1
Polar residues: 6 Hydrophobic residues: 3
Hydrophobicity: -9.17 Boman Index: -562
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 24.17
Instability Index: 5555 Extinction Coefficient cystines: 7115
Absorbance 280nm: 646.82

Literature

  • PubMed ID:  10548501
  • Title:  Urotensin II Is the Endogenous Ligand of a G-protein-coupled Orphan Receptor, SENR (GPR15)