General Information

  • ID:  hor000048
  • Uniprot ID:  P20156
  • Protein name:  Neuroendocrine regulatory peptide-2
  • Gene name:  Vgf
  • Organism:  Rattus norvegicus (Rat)
  • Family:  VGF family
  • Source:  animal
  • Expression:  By nerve growth factor.|Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells. VGF and several of the derived peptides are present in the brain.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Rattus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity; GO:0008083 growth factor activity
  • GO BP:  GO:0001541 ovarian follicle development; GO:0002021 response to dietary excess; GO:0006091 generation of precursor metabolites and energy; GO:0007165 signal transduction; GO:0009409 response to cold; GO:0019953 sexual reproduction; GO:0030073 insulin secretion; GO:0030182 neuron differentiation; GO:0032868 response to insulin; GO:0042593 glucose homeostasis
  • GO CC:  NA

Sequence Information

  • Sequence:  QAEATRQAAAQEERLADLASDLLLQYLLQGSGARQRDLG
  • Length:  39
  • Propeptide:  NA
  • Signal peptide:  MKTFTLPASVLFCFLLLIRGLGA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons Stimulates also feeding behavior in an orexin-dependent manner in the hypothalamus. Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9QZQ4-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-Q9QZQ4-F1.pdbhor000048_AF2.pdbhor000048_ESM.pdb

Physical Information

Mass: 490570 Formula: C178H297N57O62
Absent amino acids: CFHIKMNPVW Common amino acids: AL
pI: 4.36 Basic residues: 4
Polar residues: 7 Hydrophobic residues: 16
Hydrophobicity: -51.28 Boman Index: -9236
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 100.51
Instability Index: 4334.87 Extinction Coefficient cystines: 1490
Absorbance 280nm: 39.21

Literature

  • PubMed ID:  19194657
  • Title:  Neuroendocrine Regulatory peptide-1 and -2: Novel Bioactive Peptides Processed From VGF