HORDB

ID: hor000041
Uniprot ID: Q95ZN4
Protein name: Neuropeptide-like protein 33
Gene name: nlp-33
Organism: Caenorhabditis elegans
Family: YARP (YGGW-amide related peptide) family
Source: Animal
Expression: Strongly up-regulated upon D.coniospora infection. |Expressed in hypoderm.
Disease: NA
Comments: Strongly up-regulated upon D.coniospora infection
Taxonomy: Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0031640 killing of cells of another organism; GO:0050832 defense response to fungus
GO CC: GO:0005576 extracellular region

Sequence: QWGYGGPYGGYGGGYGGGPWGYGGGWRRRHWGGYGGGPWGGYGGGPWGGYY
Length: 51(22-72)
Propeptide: MISTSLLLVVLLFAILAIVDAQWGYGGPYGGYGGGYGGGPWGYGGGWRRRHWGGYGGGPWGGYGGGPWGGYYGK
Signal peptide: MISTSLLLVVLLFAILAIVDA
Modification: T51 Tyrosine amide
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000041_AF2.pdb

hor000041_ESM.pdb

Mass:	615859	Formula:	C250H303N69O62
Absent amino acids:	ACDEFIKLMNSTV	Common amino acids:	G
pI:	9.58	Basic residues:	4
Polar residues:	36	Hydrophobic residues:	6
Hydrophobicity:	-106.86	Boman Index:	-1686
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	0
Instability Index:	4144.51	Extinction Coefficient cystines:	46410
Absorbance 280nm:	928.2