General Information

  • ID:  hor000038
  • Uniprot ID:  O15240
  • Protein name:  Neuroendocrine regulatory peptide-2
  • Gene name:  VGF
  • Organism:  Homo sapiens (Human)
  • Family:  NA
  • Source:  Human
  • Expression:  Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.
  • Disease:  Diseases associated with VGF include Vaccinia and Pheochromocytoma.
  • Comments:  NA
  • Taxonomy:  Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0003674 molecular_function; GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity; GO:0008083 growth factor activity
  • GO BP:  GO:0001541 ovarian follicle development; GO:0002021 response to dietary excess; GO:0006091 generation of precursor metabolites and energy; GO:0007165 signal transduction; GO:0009409 response to cold; GO:0019953 sexual reproduction; GO:0030073 insulin secretion; GO:0032868 response to insulin; GO:0033500 carbohydrate homeostasis; GO:0042593 glucose homeostasis; GO:0042742 defense response to bacterium; GO:0048167 regulation of synaptic plasticity; GO:0048168 regulation of neuronal synaptic plasticity; GO:0050804 modulation of chemical synaptic transmission; GO:0051591 response to cAMP; GO:0099538 synaptic signaling via neuropeptide
  • GO CC:  GO:0005615 extracellular space

Sequence Information

  • Sequence:  QAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLG
  • Length:  38
  • Propeptide:  MKALRLSASALFCLLLINGLGAAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENYIEHVLLRRP
  • Signal peptide:  MKALRLSASALFCLLLINGLGA
  • Modification:  T1 Pyrrolidone carboxylic acid
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons Stimulates also feeding behavior in an orexin-dependent manner in the hypothalamus. Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-O15240-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000038_AF2.pdbhor000038_ESM.pdb

Physical Information

Mass: 474275 Formula: C173H290N56O58
Absent amino acids: CFHIKMNPVW Common amino acids: AL
pI: 4.67 Basic residues: 4
Polar residues: 7 Hydrophobic residues: 16
Hydrophobicity: -42.37 Boman Index: -7930
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 103.16
Instability Index: 4523.95 Extinction Coefficient cystines: 1490
Absorbance 280nm: 40.27

Literature

  • PubMed ID:  19194657
  • Title:  Neuroendocrine Regulatory peptide-1 and -2: Novel Bioactive Peptides Processed From VGF