HORDB

ID: hor000033
Uniprot ID: O44665
Protein name: Neuropeptide-like protein 30
Gene name: nlp-28
Organism: Caenorhabditis elegans
Family: YARP (YGGW-amide related peptide) family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: QWGYGGYGRGYGGYGGYGRGYGGYGRGYGGYGRGMWGRPYGGYGWGK
Length: 47
Propeptide: MISTSSILILVVLLACFMAASAQWGYGGYGRGYGGYGGYGRGYGGYGRGYGGYGRGMWGRPYGGYGWGK
Signal peptide: MISTSSILILVFLLACFMATSA
Modification: T7 Tyrosine amide;T17 Tyrosine amide;T25 Tyrosine amide;T33 Tyrosine amide;T41 Tryptophan amide
Glycosylation: NA
Mutagenesis: NA

Function: May have antimicrobial activity. May play a role in response to fungal infection.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000033_AF2.pdb

hor000033_ESM.pdb

Mass:	582704	Formula:	C231H299N67O60S
Absent amino acids:	ACDEFHILNSTV	Common amino acids:	G
pI:	10	Basic residues:	6
Polar residues:	35	Hydrophobic residues:	3
Hydrophobicity:	-119.57	Boman Index:	-5533
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	0
Instability Index:	-2132.13	Extinction Coefficient cystines:	32890
Absorbance 280nm:	715