General Information

  • ID:  hor000031
  • Uniprot ID:  O44665
  • Protein name:  Neuropeptide-like protein 28
  • Gene name:  nlp-28
  • Organism:  Caenorhabditis elegans
  • Family:  YARP (YGGW-amide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QWGYGGYGRGYGGYGGYGRGMYGGYGRGMYGGYGRGMYGGWGK
  • Length:  43
  • Propeptide:  MISTSSILILVFLLACFMATSAQWGYGGYGRGYGGYGGYGRGMYGGYGRGMYGGYGRGMYGGWGK
  • Signal peptide:  MISTSSILILVFLLACFMATSA
  • Modification:  T7 Tyrosine amide;T17 Tyrosine amide;T25 Tyrosine amide;T33 Tyrosine amide;T41 Tryptophan amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May have antimicrobial activity
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-O44665-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    AF-O44665-F1.pdbhor000031_AF2.pdbhor000031_ESM.pdb

Physical Information

Mass: 530129 Formula: C206H273N59O55S3
Absent amino acids: ACDEFHILNPSTV Common amino acids: G
pI: 9.91 Basic residues: 5
Polar residues: 32 Hydrophobic residues: 2
Hydrophobicity: -100.7 Boman Index: -3978
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: -188.37 Extinction Coefficient cystines: 25900
Absorbance 280nm: 616.67

Literature

  • PubMed ID:  NA
  • Title:  NA