General Information

  • ID:  hor000030
  • Uniprot ID:  NA
  • Protein name:  Adipokinetic hormone
  • Gene name:  NA
  • Organism:  Schistocerca gregaria
  • Family:  AKH/HRTH/RPCH family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  ELNFTPNWGT
  • Length:  10
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid amide;T10 Threonine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  This hormone, released from cells in the corpora cardiaca, causes release of diglycerides from the fat body and stimulation of muscles to use these diglycerides as an energy source during energy-demanding processes.(by similarity)
  • Mechanism:  the AKHs enhance the production of inositol phosphates (InsPn) including Ins(1,4,5)P3, which may mediate the mobilization of Ca2+ from intracellular stores and then stimulation of cAMP production.
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000030_AF2.pdbhor000030_ESM.pdb

Physical Information

Mass: 133897 Formula: C54H75N13O17
Absent amino acids: ACDHIKMQRSVY Common amino acids: NT
pI: 3.85 Basic residues: 0
Polar residues: 5 Hydrophobic residues: 3
Hydrophobicity: -82 Boman Index: -1406
Half-Life: 1 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 39
Instability Index: -3526 Extinction Coefficient cystines: 5500
Absorbance 280nm: 611.11

Literature

  • PubMed ID:  958472
  • Title:  Structure of Locust Adipokinetic Hormone, a Neurohormone That Regulates Lipid Utilisation During Flight