General Information

  • ID:  hor000022
  • Uniprot ID:  NA
  • Protein name:  hypertrehalosaemic neuropeptide
  • Gene name:  NA
  • Organism:  Nauphoeta Cinerea(Cockroach)
  • Family:  AKH/HRTH/RPCH family
  • Source:  animal
  • Expression:  cells in the corpora cardiaca
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  EVNFSPGWGT
  • Length:  10
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid amide;T10 Threonine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Adipokinetic activity
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000022_AF2.pdbhor000022_ESM.pdb

Physical Information

Mass: 125386 Formula: C50H68N12O16
Absent amino acids: ACDHIKLMQRY Common amino acids: G
pI: 3.85 Basic residues: 0
Polar residues: 5 Hydrophobic residues: 3
Hydrophobicity: -48 Boman Index: -819
Half-Life: 1 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 29
Instability Index: 3139 Extinction Coefficient cystines: 5500
Absorbance 280nm: 611.11

Literature

  • PubMed ID:  3801028
  • Title:  Amino Acid Sequence of a Hypertrehalosaemic Neuropeptide From the Corpus Cardiacum of the Cockroach, Nauphoeta Cinerea